MGF (Mechano Growth Factor)

Mechano Growth Factor, better known as MGF, is a splice variant of Insulin-Like Growth Factor-1 (IGF-1). This hormone is largely responsible for the healing and building of damaged muscle tissue post exercise or any other activity that causes damage to the muscle tissue. Although somewhat simplistic to say, the best way to view MGF is as a byproduct of IGF-1, specifically, IGF-1Ec, which represents the predominant splice in the two splice system created by IGF-1.

IGF-1 is a hormone consisting of 70 amino acids that is structurally similar to insulin. Produced by the liver, IGF-1 production is stimulated by the production and release of Growth Hormone (GH) in the body. IGF-1 affects nearly every cell in the human body, predominantly as it pertains to cellular repair. When muscle tissue is damaged, this creates a response in the body that causes IGF-1 to be spliced into two variants, IGF-1Ec and IGF-1Ea, the former being MGF.
The splice to MGF activates satellite cells causing the growth of new muscle fibers in the body. Further, the presence of MGF increases the body’s rate of protein synthesis. This will cause the body to increase muscle size and more importantly repair existing damaged muscle. The recovery factor associated with MGF is without question the most important and beneficial aspect of the hormone.
Although the function of MGF may seem slightly confusing when you first glance, the process itself is rather simple when you look at it step-by-step:
1. IGF-1 is released due to exercise (occurs post exercise)
2. IGF-1 is spliced to MGF
3. MGF activates recovery of muscle tissue via an activation of muscle stem cells